Ingredient glossary
Acetyl Tetrapeptide-5
On your shelf ✓What Acetyl Tetrapeptide-5 does for your skin, who it suits, and what to watch for.
INCI: Acetyl Tetrapeptide-5 · Also: Eyeseryl
In short: Acetyl Tetrapeptide-5 delivers de puffing and firming, earns its place for periorbital puffiness and dark circles, and the evidence behind it is emerging.
- What it does
- De puffing, firming
- Best for
- Periorbital puffiness, dark circles
- Evidence
- Emerging
- How long
- Never measured
The molecule
The Glow take
Nice to have, and nothing to overthink.
Acetyl Tetrapeptide-5 plays a quiet supporting role, rounding out a formula rather than being the reason you buy it.
— Maya
What it does
- de puffing
- firming
- dark circle support
emerging evidenceManufacturer and early clinical data report up to seventy percent reductions in periorbital edema over sixty days at around one percent though independent large-scale trials are still limited.
On a label: usually effective at 0.5-2%.
Who it's for, and who should skip it
Tends to suit
- periorbital puffiness
- dark circles
- photoaged
Approach with care
No specific group flagged to avoid it.
- Clogs poresLow
- Irritation riskLow
How it fits each skin type
- DryNeutral
- CombinationNeutral
- OilyNeutral
- SensitiveNeutral
Often chosen for periorbital puffiness, dark circles, photoaged.
Where it fits in your routine
Nobody has published how long this takes to work.
What is known, and what is missing
Measured on: Periorbital puffiness / under-eye bag severity.
What is known: the entire timing story traces to a single supplier study of 20 women applying a cream with 0.01% acetyl tetrapeptide-5 (from a 10% Eyeseryl solution) twice daily for 60 days, reported as responder percentages - 70% improved by day 15, 95% by day 60. What is missing: those are counts of subjects called improved, not a measured endpoint against placebo with a stated significance visit, and no independent peer-reviewed trial of the peptide alone exists; the peptide usually appears in blends. Responder percentages from the manufacturer are the kind of claim this column is meant to refuse, so the row stays blank despite the row's 'high' marketing popularity.
Lipotec/Lubrizol Eyeseryl supplier study, 20 subjects, 60 days; no independent placebo-controlled trial identified
Plays well with
Acetyl Tetrapeptide-5, answered
Is Acetyl Tetrapeptide-5 safe during pregnancy?
Yes. Acetyl Tetrapeptide-5 is considered safe to use during pregnancy and breastfeeding. As with anything, if you are unsure it is worth a quick word with your doctor or midwife.
Who should avoid Acetyl Tetrapeptide-5?
No specific group is flagged to avoid Acetyl Tetrapeptide-5. It is well tolerated by most skin. Still, introduce anything new one product at a time.
What concentration of Acetyl Tetrapeptide-5 actually works?
Acetyl Tetrapeptide-5 tends to do its job in the 0.5 to 2% range. Much lower and it is likely underdosed.
Compare Acetyl Tetrapeptide-5 with
Can you mix Acetyl Tetrapeptide-5 with
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