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Ingredient glossary

Leuphasyl

What Leuphasyl does for your skin, who it suits, and what to watch for.

INCI: Pentapeptide-18

Promising, not proven

In short: Leuphasyl delivers anti-aging support and wrinkle smoothing, suits most skin types, and the evidence behind it is limited.

What it does
Anti aging, wrinkle smoothing
Best for
Most skin types
Evidence
Limited
Does it clash with what you use? Check it →

Written by Maya Faour, founder and sole writer; not a dermatologistHow we work →

The molecule

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The Glow take

Nice to have, and nothing to overthink.

Leuphasyl plays a quiet supporting role, rounding out a formula rather than being the reason you buy it.

— Maya

What it does

  • anti aging
  • wrinkle smoothing

weak evidenceAn open label study on twenty volunteers reported wrinkles down about a third at two percent, and Lipotec, which sells the peptide, claims up to forty seven…

Why we say this
  • An open label study on twenty volunteers reported wrinkles down about a third at two percent, and Lipotec, which sells the peptide, claims up to forty seven percent at five percent.
  • No placebo control and no independent trial have been published.

On a label: usually effective at 2-10%.

The neuromodulating peptide family, at a glance

4 neuromodulating peptide entries in the base, Leuphasyl among them. 3 of the 4 are an active.

  1. Syn-Ake496 Da
  2. Leuphasyl570 Da
  3. Acetyl Dipeptide-1604 Da
  4. Argireline887 Da
What the family shares: 3 of the 4 are an active in the base; the rest carry other roles.Ordered by molecular mass, lightest first, from PubChem's formulas.

How much do you need?

Not established

No human trial pins a dose. The reasoning is below, and it is the honest answer.

Why we say this
  • Not established at a stated concentration in a vehicle-controlled leave-on trial: The ingredients were grouped according to their content in the cosmetic formulation and assigned to one of the following ranges: (A) 50-100 wt.%; (B) 25-50 wt.%; (C) 10-25 wt.%; (D) 5-10 wt.%; (E) 1-5 wt.%; (F) 0.1-1 wt.%; (G) <0.1 wt.%; (H) traces.

Who it's for, and who should skip it

Tends to suit

  • normal
  • combo
  • photoaged

Approach with care

No specific group flagged to avoid it.

  • Clogs poresLow
  • Irritation riskLow

How it fits each skin type

  • DrySuits
  • CombinationSuits
  • OilySuits
  • SensitiveSuits

Often chosen for photoaged.

Where it fits in your routine

WhenMorning or evening
Where in the orderAfter cleansing, before your moisturizer

Plays well with

  • other peptides
  • humectants

Leuphasyl, answered

Is Leuphasyl safe during pregnancy?

Yes. Leuphasyl is considered safe to use during pregnancy and breastfeeding. As with anything, if you are unsure it is worth a quick word with your doctor or midwife.

Who should avoid Leuphasyl?

No specific group is flagged to avoid Leuphasyl. It is well tolerated by most skin. Still, introduce anything new one product at a time.

What concentration of Leuphasyl actually works?

Leuphasyl tends to do its job in the 2 to 10% range. Much lower and it is likely underdosed.

Compare Leuphasyl with

26 comparisons built.

This, for every label you own

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Sources & how we reviewed this

Last reviewed . Educational information about a cosmetic ingredient, not medical advice.

What changed on this page

  • : the effective dose from trials, the highest dose tested
  • : what the EU regulates
  • : the PubChem record, light stability

See the full changelog →