Head to head
Differin Adapalene Gel 0.1% vs Medik8 Liquid Peptides
Same comparison whichever way you searched it: Medik8 Liquid Peptides vs Differin Adapalene Gel 0.1%.
The bottom lineDifferin Adapalene Gel 0.1% and Medik8 Liquid Peptides land in much the same place on performance, so value decides it: Differin Adapalene Gel 0.1% does the same job for less.
Medik8 Liquid Peptides keeps clear of pregnancy-flagged actives, while Differin Adapalene Gel 0.1% carries one that is best paused in pregnancy.
Answer nine questions and the app picks between them for your skin.
Cost per use
€0.23 an applicationabout 75 uses from 15 ml
a usual amount, not a measured dose: 3-5 drops, about 0.2 ml; from €17 as read in September 2026 and a 15 ml pack.
how this is counted
About €0.23 an application, about 75 uses from 15 ml.
- a convention: no trial has measured a serum dose
- Measured or assumed: the rule, and the dose table
€0.35 an applicationabout 150 uses from 30 ml
a usual amount, not a measured dose: 3-5 drops, about 0.2 ml; from €52 as read in September 2026 and a 30 ml pack.
how this is counted
About €0.35 an application, about 150 uses from 30 ml.
- a convention: no trial has measured a serum dose
- Measured or assumed: the rule, and the dose table
Per application, Differin Adapalene Gel 0.1% is the cheaper: €0.23 against €0.35.
Which should you pick?
Pick Adapalene Gel 0.1% if
- you are dealing with breakouts and oiliness
- you want the more affordable option
- your breakouts are the fungal kind (Malassezia): nothing on its label was measured to feed the yeast
Pick Liquid Peptides if
- your barrier feels stressed and needs the support
- plump, lasting hydration is what you want
- you are pregnant or breastfeeding
What each delivers
Side by side
| Adapalene Gel 0.1% | Liquid Peptides | |
|---|---|---|
| Type | Serum | Serum |
| Key actives | Adapalene | Glycerin, Hyaluronic acid, Pro-vitamin B5 |
| Texture | A light, fast-absorbing texture that layers cleanly under the rest of your routine, with no greasy film. | A light, fast-absorbing texture that layers cleanly under the rest of your routine, with no greasy film. |
| Fragrance | None detected | None detected |
| Feeds Malassezia | none measured / none inferred | 1 measured / none inferred |
| Pregnancy | One caution | No flagged actives |
| Ingredients | 8 listed | 35 listed |
| Price | ~€17 | ~€52 |
What's in one but not the other
The two labels share 0 of the 43 ingredients between them. The actives are where they part company.
What each one adds acts on The living epidermis for Differin Adapalene Gel 0.1% and The stratum corneum, Not established for Medik8 Liquid Peptides. That is the layer each is understood to act on, not how deep it travels.
Only in Differin Adapalene Gel 0.1%
Both
nothing
Only in Medik8 Liquid Peptides
Medik8 Liquid Peptides is a different bottle only for: glycerin, hyaluronic acid, pro-vitamin b5, palmitoyl tripeptide-1, argireline, matrixyl synthe'6. They share nothing.
The molecule doing the work
Better for…
- Breakouts & congestionAdapalene Gel 0.1%
- Dryness & dehydrationLiquid Peptides
- Sensitive, reactive skinLiquid Peptides
Who each suits
- Differin Adapalene Gel 0.1%
- one named active, so no type two of them agree on · avoid with breastfeeding, pregnancy and very sensitive skin
- Medik8 Liquid Peptides
- dry, combination, normal
Differin Adapalene Gel 0.1% is the cheaper of the two (~€17 vs ~€52).
Ready to pick one?
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Common questions
Is Differin Adapalene Gel 0.1% or Medik8 Liquid Peptides better for breakouts & congestion?
For breakouts & congestion, Differin Adapalene Gel 0.1% is the stronger pick by our read of the two formulas. Differin Adapalene Gel 0.1% and Medik8 Liquid Peptides land in much the same place on performance, so value decides it: Differin Adapalene Gel 0.1% does the same job for less. Medik8 Liquid Peptides keeps clear of pregnancy-flagged actives, while Differin Adapalene Gel 0.1% carries one that is best paused in pregnancy.
Which is cheaper, Differin Adapalene Gel 0.1% or Medik8 Liquid Peptides?
Differin Adapalene Gel 0.1% is the cheaper of the two (~€17 vs ~€52).
Can I use Differin Adapalene Gel 0.1% and Medik8 Liquid Peptides together?
They are both serums, so you would normally pick one rather than layer both in the same step. You can keep both and alternate them (morning and night, or on different days) if you like variety, but you do not need two.
Compare it with…
41 duels are built for this serum, Celimax The Vita A Retinal Shot Tightening Booster and La Roche-Posay Hyalu B5 Suractivated Serum among them: type a name, or pick one below.