Head to head
La Roche-Posay Hyalu B5 Suractivated Serum vs Medik8 Liquid Peptides
Same comparison whichever way you searched it: Medik8 Liquid Peptides vs La Roche-Posay Hyalu B5 Suractivated Serum.
The bottom lineLa Roche-Posay Hyalu B5 Suractivated Serum and Medik8 Liquid Peptides are close on what they deliver, so it comes down to your skin: Medik8 Liquid Peptides is the kinder pick for sensitive or reactive skin since it is fragrance-free.
Answer nine questions and the app picks between them for your skin.
La Roche-PosayHyalu B5 Suractivated SerumSee every ingredient in Hyalu B5 Suractivated Serum, decoded
Cost per use
$0.27 an applicationabout 150 uses from 30 ml
a usual amount, not a measured dose: 3-5 drops, about 0.2 ml; from $40 as read in September 2026 and a 30 ml pack.
how this is counted
About $0.27 an application, about 150 uses from 30 ml.
- a convention: no trial has measured a serum dose
- Measured or assumed: the rule, and the dose table
€0.35 an applicationabout 150 uses from 30 ml
a usual amount, not a measured dose: 3-5 drops, about 0.2 ml; from €52 as read in September 2026 and a 30 ml pack.
how this is counted
About €0.35 an application, about 150 uses from 30 ml.
- a convention: no trial has measured a serum dose
- Measured or assumed: the rule, and the dose table
Per application, La Roche-Posay Hyalu B5 Suractivated Serum is the cheaper: $0.27 against €0.35.
Which should you pick?
Pick Hyalu B5 Suractivated Serum if
- dark spots, dullness or an uneven tone are your focus
- you want the more affordable option
- your breakouts are the fungal kind (Malassezia): nothing on its label was measured to feed the yeast
Pick Liquid Peptides if
- your skin is sensitive or reacts to fragrance
What each delivers
Side by side
| Hyalu B5 Suractivated Serum | Liquid Peptides | |
|---|---|---|
| Type | Serum | Serum |
| Key actives | Glycerin, Pro-vitamin B5, Hyaluronic acid | Glycerin, Hyaluronic acid, Pro-vitamin B5 |
| Texture | A light, fast-absorbing texture that layers cleanly under the rest of your routine, with no greasy film. | A light, fast-absorbing texture that layers cleanly under the rest of your routine, with no greasy film. |
| Fragrance | Contains fragrance | None detected |
| Feeds Malassezia | none measured / none inferred | 1 measured / none inferred |
| Pregnancy | No flagged actives | No flagged actives |
| Ingredients | 32 listed | 35 listed |
| Price | ~$40 | ~€52 |
What's in one but not the other
The two labels share 8 of the 59 ingredients between them. The actives are where they part company.
What each one adds acts on The living epidermis, Not established for La Roche-Posay Hyalu B5 Suractivated Serum and Not established for Medik8 Liquid Peptides. That is the layer each is understood to act on, not how deep it travels.
Only in La Roche-Posay Hyalu B5 Suractivated Serum
Only in Medik8 Liquid Peptides
Medik8 Liquid Peptides is a different bottle only for: palmitoyl tripeptide-1, argireline, matrixyl synthe'6.
Where each label stops telling you the dose
Ingredients are listed in order of how much is inside, but only down to 1%. Below that the brand may list them in any order it likes, so the bottom of a label is a set, not a ranking. These two stop being a ranking in very different places.
La Roche-Posay Hyalu B5 Suractivated Serum
ordered for its first 81%
- 1Aqua/Water/Eau
- 2Glycerin
- 3Alcohol Denat
- 4Propylene Glycol
- 5Panthenol
- 6Pentylene Glycol
- 7Dimethicone
- 8PEG-6 Caprylic/Capric Glycerides
- 9Alpinia Galanga Leaf Extract
- 10Calcium Chloride
- 11Glyceryl Isostearate
- 12Madecassoside
- 13PPG-6-Decyltetradeceth-30
- 14Sodium Acetylated Hyaluronate
- 15Sodium Hyaluronate
- 16Algin
- 17Adenosine
- 18Ammonium Polyacryloyldimethyl Taurate
- 19Propanediol
- 20Hydrolyzed Hyaluronic Acid
- 21Hydroxyacetophenone
- 22Caprylic/Capric Triglyceride
- 23Caprylyl Glycol
- 24Citric Acid
- 25Trisodium Ethylenediamine Disuccinate
- 26Acetyl Glucosamine
- 27Xanthan Gum
- 28Butylene Glycol
- 291,2-Hexanediol
- 30Tocopherol
- 31Phenoxyethanol
- 32Parfum/Fragrance
6 of 32 sit below the line, marked by Xanthan Gum.
Medik8 Liquid Peptides
ordered for its first 54%
- 1Aqua (Water)
- 2Glycerin
- 3Butylene Glycol
- 4Palmitoyl Tetrapeptide-7
- 5Palmitoyl Tripeptide-1
- 6Copper Heptapeptide-14 Pantothenate
- 7Heptapeptide-15 Palmitate
- 8Arginine/Lysine Polypeptide
- 9Palmitoyl Tripeptide-38
- 10Carnosine
- 11Acetyl Hexapeptide-8
- 12Pentapeptide-18
- 13Palmitoyl Tripeptide-5
- 14Tetrapeptide-21
- 15Sodium Hyaluronate
- 16Inulin
- 17Alpha-Glucan Oligosaccharide
- 18Lactic Acid/Glycolic Acid Copolymer
- 19Panthenol
- 20Ethylhexylglycerin
- 21Hydroxypropyl Cyclodextrin
- 22Dunaliella Salina (Green Algae) Extract
- 23Polysorbate 20
- 24Caprylyl Glycol
- 25Citric Acid
- 26Glyceryl Caprylate
- 27Pantolactone
- 28Phenylpropanol
- 29Polyvinyl Alcohol
- 30Carbomer
- 31Potassium Sorbate
- 32Sodium Benzoate
- 33Sorbic Acid
- 34Phenoxyethanol
- 35Xanthan Gum
16 of 35 sit below the line, marked by Ethylhexylglycerin.
Below the line is not too little to work: ceramides, retinoids and peptides all act far under a percent. It means the position stops carrying information. Where the line falls is inferred from the first ingredient whose whole job is done at a fraction of a percent, so it is a close read of the label rather than a number from the formula sheet.
The molecule doing the work
Better for…
- Dark spots & uneven toneHyalu B5 Suractivated Serum
- Dryness & dehydrationEither works
- Sensitive, reactive skinLiquid Peptides
Who each suits
- La Roche-Posay Hyalu B5 Suractivated Serum
- dry, sensitive, normal
- Medik8 Liquid Peptides
- dry, combination, normal
La Roche-Posay Hyalu B5 Suractivated Serum is the cheaper of the two (~$40 vs ~€52).
Ready to pick one?
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Common questions
Is La Roche-Posay Hyalu B5 Suractivated Serum or Medik8 Liquid Peptides better for dark spots & uneven tone?
For dark spots & uneven tone, La Roche-Posay Hyalu B5 Suractivated Serum is the stronger pick by our read of the two formulas. La Roche-Posay Hyalu B5 Suractivated Serum and Medik8 Liquid Peptides are close on what they deliver, so it comes down to your skin: Medik8 Liquid Peptides is the kinder pick for sensitive or reactive skin since it is fragrance-free.
Which is cheaper, La Roche-Posay Hyalu B5 Suractivated Serum or Medik8 Liquid Peptides?
La Roche-Posay Hyalu B5 Suractivated Serum is the cheaper of the two (~$40 vs ~€52).
Can I use La Roche-Posay Hyalu B5 Suractivated Serum and Medik8 Liquid Peptides together?
They are both serums, so you would normally pick one rather than layer both in the same step. You can keep both and alternate them (morning and night, or on different days) if you like variety, but you do not need two.
Compare it with…
41 duels are built for this serum, The Ordinary Hyaluronic Acid 2% + B5 (Original Formulation) and The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides) among them: type a name, or pick one below.