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How much acetylated hyaluronic acid do you need? 0.1%+

The effective acetylated hyaluronic acid percentage, by the vehicle-controlled trials, starts at 0.1%; no published dose comparison sets a ceiling.

This one works on contact: there is nothing to wait for.

how it was measured

Measured on visible surface smoothing and wrinkle filling from the applied film - crow's-feet wrinkle count and nasolabial wrinkle area, imaged 6 hours after a single application against a placebo-treated half-face; measured at the trial's end, so possibly sooner.PMID 34708918

See it on the timeline, beside the others →

Written by Maya Faour, founder and sole writer; not a dermatologistHow we work →Published Reviewed

Dose line for Acetylated Hyaluronic Acid: the trials worked from 0.1% with no measured ceiling; ticks at 0.1%, 0.2% where the named trials worked. Linear scale.0.1%0.2%0.1%0.2%0%0.23%

0.1%.

The multi-week arms used 0.1%: twice daily it gave 9% fewer nasogenian wrinkles and 12% smaller wrinkle area than placebo at day 28 in 20 women, and 9% less roughness at day 56 in 30 women.

The rose band is where the vehicle-controlled trials worked, open to the right because no dose comparison sets a ceiling; each tick is a concentration a named trial used, with its author and year; no product in our catalogue declares a percentage on the name. The scale is linear (0 to 0.23%).

What acetylated hyaluronic acid percentage is effective?

The multi-week arms used 0.1%: twice daily it gave 9% fewer nasogenian wrinkles and 12% smaller wrinkle area than placebo at day 28 in 20 women, and 9% less roughness at day 56 in 30 women.

0.1%+

The trials, and what they used
  • One supplier, three placebo-controlled half-face studies published together (Meunier 2022, Givaudan, full text read; the abstract states no concentration).
  • The multi-week arms used 0.1%: twice daily it gave 9% fewer nasogenian wrinkles and 12% smaller wrinkle area than placebo at day 28 in 20 women, and 9% less roughness at day 56 in 30 women.
  • The 0.2% arm is a six-hour reading: 6% fewer crow's-feet wrinkles on silicone replicas than the placebo side after one application on 21 women aged 42 to 70, a film effect.
  • Effect sizes are single-digit percentages, the concentrations differ between the flash and the multi-week arms, and nobody independent has repeated it.
  • No dose comparison found, and no head-to-head against plain sodium hyaluronate at matched dose, so the claim that it out-hydrates ordinary hyaluronate is unshown.

Is more than 0.1% acetylated hyaluronic acid better?

Nobody has measured it: no published dose comparison sets a ceiling for acetylated hyaluronic acid, so a percentage above 0.1% is above the trials' floor, not above a measured maximum.

No published dose comparison sets a ceiling for acetylated hyaluronic acid. A declared percentage above 0.1% is above the trials' floor, not above a measured maximum: the trials say from 0.1% it works, and say nothing about whether more does more.

What does the acetylated hyaluronic acid percentage on a label tell you?

A name that states a percentage ("Acetylated Hyaluronic Acid 0.1%") is the only amount a cosmetic label ever declares, so it is the one number that can be read against the trials: at or above the 0.1% floor, or below it.

A name without a percentage leaves the position. The rules make a brand list ingredients in descending order of amount down to 1%, and in any order below it, so acetylated hyaluronic acid above the 1% line is at least 1% and acetylated hyaluronic acid below it can be any trace the brand likes. The floor the trials worked from is 0.1%, and a position alone cannot tell you whether a label reaches it.

The acetylated hyaluronic acid percentages in our catalogue

No product in our catalogue is sold on acetylated hyaluronic acid yet.

Read on

Other actives with a dose the trials pinned:

The range column was researched and verified in September 2026 (this row last changed 14 September 2026). The number is the trials' and the reasoning is the knowledge base's; neither is advice about your skin. How we score.